Sentence examples for significantly trait from inspiring English sources

The list of significantly trait correlated transcripts was analyzed according to predefined pathways and functional categories annotated by KEGG [ 28], and GO [ 74] using the DAVID bioinformatic resource [ 75].

Some (4%) significantly trait-associated SNPs or their LD partners overlapped with none of the genomic features with a positive influence on trait-association status.

We established odds ratios of functional annotations that are more likely to contain significantly trait-associated SNPs, for the purpose of prioritizing GWAS hits for further studies.

Additional file 12 shows the effect of including distance to TSS for six representative genomic annotations for the significantly trait-associated SNPs.

While significantly trait-associated SNPs are consistently documented, suggestive associations often remain unreported, since they are assumed to contribute less to our understanding of the underlying biology.

The common genome-wide level significance threshold (p < 5 × 10-8) was used to define 1,909 significantly trait-associated SNPs from 586 studies.

Distance to transcription start site (TSS) was identified as an influential factor, where SNPs further away from the TSS were less likely to be significantly trait-associated.

The majority of significantly trait-associated SNPs and their LD partners (55%) overlap in regions identified as containing genes listed in the vega database [ 29, 38].

For the significantly trait-associated SNPs we observed significant enrichment in genic annotations and several features associated with particular chromatin states.

Here, we investigated the genomic signature of 1,909 significantly trait-associated SNPs (P-value < 5 × 10-8) by analyzing the overlaps between regions annotated for 58 genomic features with the associated variants and their LD SNP partners.

As expected among the genomic features enriched for significantly trait-associated SNPs were the OMIM morbid regions, identified as regions associated with traits in GWAS and linkage studies [ 29]; these regions may approximate a positive control.