The mean ferritin concentrations also did not differ significantly two weeks after surgery.
Deeper areas of the cartilage were only affected significantly six weeks after the injection of 500 U collagenase, as indicated by CMLW at the midzone (50% depth, Figure 7B), with 26 ± 6% (P <0.001) of the MTP width losing at least 50% of its depth.
Serum phosphate levels decreased significantly three 3 weeks after the FCM administration, and remained at lower levels at week 12. Serum calcium, PTH and 1,25-vit D levels did not change during the study.
However, in our study neither the PCS nor the MCS changed significantly during three weeks of doxycycline or placebo treatment.
In normally fed mice, PPAR δ protein increased significantly after three weeks of moderate treadmill exercise, but short-term effects were not investigated in this study (Luquet et al., 2003).
Peeking rate differed significantly between the three weeks of observation (F2,264 = 4.40, P = 0.013) with lower frequencies during the week preceding disturbance (1.01±0.13) than during the week of disturbance (1.42±0.13) (t229 = −2.66, P = 0.022).
The treatment effect on flare of dexamethasone versus placebo differed significantly between the three weeks (P = 0.007).
Combining both groups' data, function and pain were significantly improved at three weeks (mean difference −2.3; 95% CI: 1.2 to 3.5; p< 0.001).
BW did not alter significantly during the three weeks of repeated ISO and MMF anaesthesia, except at one time point with MMF (run 4).
In addition, the proliferation index measured as percentage of cells expressing Ki67 protein decreased over time, the percentage of proliferating cells was significantly lower after three weeks compared to one and two weeks in culture (p < 0.05).
