More significantly, mitochondrial replacement involves modification of the human germ-line, with donor mitochondria being transmitted to future generations through the maternal line.
The deactivation of solid acid catalysts during the alkylation of isobutane with butene has significantly impeded replacement of the commonly used homogeneous catalysts.
This, along with aggressive advertising for oil and filter changes at regular intervals, expects to significantly drive replacement demand of oil filters, according to new research from market research company Frost & Sullivan.
Its stock is priced 20% below book value and significantly below replacement value.
Significantly, no replacement awards have been made, nor has the award been repriced.
"I was at a cocktail party on a Wednesday night in 1989, and a trophy building on the Westside went down at some $420 a square foot, significantly above replacement cost.
According to the New York Times, Amtrak's Northeast Corridor needs a $28 billion overhaul, including, most significantly, the replacement tunnel under the Hudson River connecting New York and New Jersey.
We might see more countries entering a "birth dearth," i.e., birth rates falling significantly below replacement levels, which Japan and other places are experiencing.
The original GWAS tag SNP remained the most significant association for just 4 of these, while at 35 regions, we identified a more significantly associated replacement lead SNP.
