Sentence examples for significantly reduced activity from inspiring English sources
Analogues 11, 12b, 12f and 13 were all more active than α-GalCer 1, whilst the remaining analogues tested displayed significantly reduced activity relative to α-GalCer.
Dr. Ping Yang of the Mayo Clinic in Rochester, Minn., has found that significantly reduced activity of a gene called GPC5 is associated with lung cancer in people who never smoked.
In addition, the length of the connective chain plays critical role in the biological activities, thus cyclic the derivative 7 preserved some pharmacological activity but derivative 5 with two carbon atom shorter chain showed significantly reduced activity.
Interestingly, replacement of the primary amine of 6a with a methyl group, 6b, significantly reduced activity.
The 10 mutations identified in ilvA code for enzymes with significantly reduced activity relative to that of wild-type threonine deaminase.
In contrast to the mutations at the hydrophobic residues I167 and F212, the mutations at polar amino acid residues S168, N173 and Q178 did not exhibit significantly reduced activity (Table 2).
The E4A4, Δ12-39 and KKAA Nef mutants displayed significantly reduced activities relative to wt Nef, however retained detectable Pak2 association.
Among these, about half display no or very low activity and the others, although they behave like native Gap1 in growth tests, display significantly reduced activities.
In fact, the diabetic mice displayed significantly reduced activities of these major clearance enzymes (NEP IDEE; p ≤ 0.01 for both), compared to non-diabetic mice.
More recently, significantly reduced activities but normal concentrations of all respiratory complexes were found in a patient who died of PRIS [ 36], and complex IV was affected most.
XOD activity was significantly elevated in CCl4-treated group, while co-treatment with thyme tincture and syrup could significantly reduce activity of this enzyme.
