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We recently identified mutations in RPS15 (all around a hotspot region) as novel significantly recurrent mutations in CLL in a series of 538 CLLs profiled by WES16.
(Kernel Convolution - a Statistical Method for Aberrant Region detection) determines which CNAs are significantly recurrent within a tumor group [ 18].
For instance, we discriminated three significantly recurrent coherent FFL motifs from our combinatorial regulatory network, most of which involve the ascertained cancer-related transcription factor MYC. Coherent FFLs are often used to amplify target genes or reduce target genes to inconsequential levels.
What are the features of a realistic background model that allow for the identification of statistically significantly recurrent and therefore more likely functional alterations?
First, we performed a cross species analysis using KC-SMART [ 18], which identifies significantly recurrent CNAs within each tumor group.
First we used KC-SMART [ 18], which identifies significantly recurrent gains and losses within each tumor group.
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Significantly fewer recurrent ankle sprains were found in the fully adherent group compared to the group that was not adherent (relative risk = 0.63; 95% CI: 0.43 0.99).
According to 3 randomized trials, the levonorgestrel-releasing intrauterine system significantly reduced recurrent endometriosis-related pelvic pain at postoperative year 1.
Elevation of the plasma peptidase activity correlated significantly with recurrent hepatitis C virus (HCV) infection in these liver recipients with a P value <0.02.
Multivariate logistic regression analysis showed concurrent slings to be associated with significantly fewer recurrent cystoceles (odds ratio, 0.32; P =.005), whereas the presence of mesh remained significantly predictive of fewer cystocele recurrences in this analysis.
Sung et al. observed significantly less recurrent bleeding at 48 h in patients treated by ligation and octreotide compared with in those treated by ligation alone [37].
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