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Our results revealed that EC-SOD-/ mice showed significantly profound I/R injury compared with WT littermates.
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These defects were significantly more profound in cells deficient for both ezrin and moesin [12], indicating that there is significant functional redundancy between ezrin and moesin in mature T cells.
Each of these cardiac haemodynamic effects was significantly more profound in the 2ADX group.
The decrease in cytokine levels was significantly more profound compared to the moderate suppression of macrophage recruitment.
For GOS/FOS and GOS/FOS/AOS, all effects on TNF-α production were significantly more profound compared to the effects of corresponding glucose/lactose controls.
The decrease of anti-CCP was significantly more profound in the P-group when the calculation was based on the patients who strictly followed randomisation and dose.
First, there may have been a significantly more profound hemoconcentration in the sepsis group in comparison to the non-sepsis group at baseline [ 17, 18].
Importantly, concurrent inhibition of either MET and VEGF or MET and MEK circumvents this compensation and provides significantly more profound inhibition of tumor growth.
Indeed, the lymphocytic toxicity noted in the present study was significantly less profound that the one noted in previous studies with docetaxel chemo radiotherapy without amifostine.
Of note, the metastasis to the lung was significantly more profound than that observed in IRF5-deficient mice; this observation is consistent with the above in vitro data, which shows that the IRF5 pathway contributes partly to Dectin-1 signaling.
In contrast, RITA-adapted cells showed only moderate resistance to irradiation with the observed effects being significantly less profound than in the nutlin-3 or cytotoxic drug-adapted cells.
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CEO of Professional Science Editing for Scientists @ prosciediting.com