Exact(5)
Axonal guidance signaling pathway is in the top 2 significantly pathways enriched in the canonical pathway analysis.
For each of these, we identified statistically significantly pathways from the KEGG database (Kanehisa et al., 2012), which are listed in Table 2.
Regulation of G1/S transition and cross-talk between VEGF and angiopoietin-1 signalling are the two most significantly pathways targeted by down-miR.
The top significantly impacted pathways from each gene list are depicted in Figure 4. Using a threshold p value of 0.05, a total of 47 pathways were regulated by in vivo TNT treatment, 40 pathways were evidently affected by in vitro TNT exposure, and 38 significantly pathways were obtained by analyzing the common 341 genes alone.
From the DEA between aggressive BC and NS for all samples BC TCGA we obtained 3225 DEGs and 254 differentially expressed miRNAs, and a list of 48 significantly pathways enriched from DEGs in total represented a list of 2214 unique genes.
Similar(55)
Pathways with a Q-value was less than 0.05 were defined as a significantly pathway enriched with differential gene expressions.
Significantly, pathway inhibitor studies revealed c-src to be an important regulator of ER loss, since its inhibition rapidly restored ER levels.
Pathway analysis revealed seven significantly altered pathways in the WikiPathways human pathway collection.
Pathway-based functional interaction network and significantly enriched pathways in ALL. Figure S38 : Pathway-based functional interaction network in ALL.
To examine this huge amount of regulated transcripts, we decided to apply global pathway analysis to identify significantly regulated pathways.
List of significantly mutated pathways identified in OTSCC by GSEA pathway analysis or comparisons with well-recognized cancer-related pathways.
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