significantly off target

USAGE SUMMARY

"significantly off target" is correct and usable in written English. You can use it to describe something that deviates greatly from a goal or expected outcome. For example: "The project's budget was significantly off target, leading to financial concerns." Alternative expressions include "far from the mark" and "well off the mark."

✓ Grammatically correct

News & Media

Science

Human-verified examples from authoritative sources

Exact Expressions

1 human-written examples

That educated guess is going to be right on the money for some people but significantly off target for others because, well, we are all very different.

Vice

Human-verified similar examples from authoritative sources

Similar Expressions

59 human-written examples

UNA inserts reduce duplex Tm values by 5 to 10 °C per insert,[ 23] they facilitate antisense strand selection as the RISC guide, and UNA modifications to the seed region of a siRNA guide strand can significantly reduce off target effects.[ 44] The comparable extent of destabilization of UNA and 2′-SCF3 modifications prompted us to explore a potential role of the latter in siRNA approaches.

Chemistry - A European Journal

Further, advanced technologies such as proton beam therapy that precisely target tumor and significantly reduce off-target damage to vital organs and healthy tissues.

Advances in Radiation Oncology

The advantage of positive allosteric modulators is that they can possess specificity and selectivity profiles as well as concentration-independent limits on activity that can significantly reduce off-target effects in vivo.

Drug Discovery Today

In addition, we have observed that one sgRNA does not trigger mutations in Cas9 nickase transgenic flies, suggesting that the Cas9 nickase system significantly prevents off-target effects.

G3: Genes, Genomes, Genetics

Hybridization-based methods exhibit significantly more off-target capture than other enrichment methods, do not capture repetitive sequences, and poorly cover GC- and AT-rich regions.

Genome Medicine

By contrast, our biological data shows significantly higher off-target rates than predicted with 7.4% (10 of 136; HFA) and 2.3% (1 of 43; SRSF) predicted off-target clones being identified (Table  3).

BMC Genomics

He blazed off target.

The Guardian - Sport

This made off target effects unlikely.

BMC Genomics

When a new target signal is significantly off-axis, directional microphones lead to slower target orientation, more complex movements, and more reversals.

Hearing Research

In the novel shRNA library, there are about tens of different shRNAs targeting one gene, and thus significantly avoids the off-target effects.

Biochemical and Biophysical Research Communications

Expert writing Tips

Best practice

Use "significantly off target" when you want to emphasize a large deviation from an expected or desired outcome. This phrase can be effective in highlighting the magnitude of the error or miscalculation.

Common error

Avoid using "significantly off target" in very casual conversations. While grammatically correct, it may sound overly formal or technical in everyday settings. Opt for simpler phrases like "way off" or "not even close" in informal contexts.

Linguistic Context

The primary grammatical function of "significantly off target" is to act as an adjectival phrase modifying a noun or concept. It describes the extent to which something deviates from an expected or intended outcome. Ludwig indicates that it's a valid and usable phrase.

Expression frequency: Rare

Frequent in

Science

50%

News & Media

50%

Formal & Business

0%

Less common in

Encyclopedias

0%

Wiki

0%

Reference

0%

Ludwig's WRAP-UP

The phrase "significantly off target" is used to describe a considerable deviation from an intended goal or expected outcome. Ludwig confirms its grammatical correctness and usability in written English. While relatively rare, the phrase is found in both news and scientific contexts, lending itself to neutral and formal registers. When a less formal tone is needed, consider alternatives such as "way off base" or "nowhere near the target".

More alternative expressions

Phrases that express similar concepts, ordered by semantic similarity:

well wide of the mark

Uses an idiom to suggest a large miss.

way off base

Uses an informal idiom to indicate a significant error.

nowhere near the target

Emphasizes the failure to come close to the intended target or goal.

substantially inaccurate

Highlights the level of inaccuracy, focusing on the deviation from the correct value or result.

completely out of range

Suggests that something is beyond the acceptable or expected limits.

markedly erroneous

Focuses on the error being noticeable or distinct.

grossly miscalculated

Highlights a large error in calculation or estimation.

considerably misguided

Emphasizes the misdirection or flawed nature of the approach.

a long way off

Indicates that something is distant from being achieved or correct.

far from the truth

Highlights that the statement or assumption is very different from reality.

FAQs

How can I use "significantly off target" in a sentence?

You can use "significantly off target" to describe something that greatly deviates from a planned or expected outcome. For example, "The project's budget was significantly off target, leading to financial concerns."

What are some alternatives to "significantly off target"?

Some alternatives include "well wide of the mark", "nowhere near the target", or "considerably misguided" depending on the specific context.

Is it appropriate to use "significantly off target" in formal writing?

Yes, "significantly off target" is suitable for formal writing, especially when describing data, results, or projections that differ substantially from what was expected or planned. It is commonly used in scientific, technical, and business contexts.

What does it mean when something is described as "significantly off target"?

It means that there is a substantial discrepancy between the actual result and the intended goal or predicted outcome. The term implies a noteworthy level of deviation that warrants attention or further investigation.