Exact(4)
"We have realized still we can improve significantly nuclear designs and this is what is being done," he said.
This suggests that in contrast with transfected PtdIns5 P 4-kinase IIα [ 13, 18], the endogenous enzyme is significantly nuclear.
Significantly, nuclear expression of YB-1 was associated with poorer overall and event-free survival (log-lank test, P=0.014 in overall survival, P=0.006 in event-free survival; Figure 9).
Significantly, nuclear accumulation of all of the cargo proteins containing Impα/β1-recognized NLSs was reduced (P<0.01) in the presence of ivermectin, whereas no such effect was observed for TRF1, which is transported to the nucleus in a manner dependent on Impβ1 alone.
Similar(4)
Furthermore, HSP70 also significantly inhibited nuclear translocation of nuclear factor-κB and degradation of IκBα induced by TNF-α.
Human GCK showed significantly decreased nuclear localisation in the presence of P446L-hGKRP (Fig. 2d; 57.5 ± 2.1% vs 80.4 ± 1.8% nuclear fluorescence; p < 0.001).
DSG significantly increased nuclear expression of ERβ.
At 150 nM, both SINE compounds significantly increase nuclear localization of NLS-mCherry-NES, with slightly slower kinetics than LMB.
Related(1)
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