In the univariate Cox regression, nuclear area was also a significantly negative prognostic factor, i.e., the ability to metastasize was higher in melanomas with larger nuclei.
Further subset analyses of these two groups of patients showed, that amongst the lower tumor burden patients (⩽10% bone marrow plasmacytosis), t(11 14) was the only significantly negative prognostic factor.
The model was based on the hazard ratio coefficients of six significantly negative prognostic factors for survival.
Presence of extracapsular extension and an increased number of positive nodes are statistically significantly negative prognostic factors for OS.
Therefore, we constructed a prognostic-score model based on the six most significantly negative prognostic factors identified in patients following IMRT, as described above.
Significantly negative prognostic factors included Karnofsky Performance Status ⩽70, age >50 years, late complications, recurrent T3 4 stage, synchronous nodal recurrence and GTV-nx >30 cm.
22 In conclusion, this study showed the presence of ECE, an increased number of positive nodes and patients with MKP as statistically significantly negative prognostic factors for OS.
In our study, graduates who chose psychiatry scored significantly higher on the negative factor 'had to do something', but also on the factor 'using one's intellect to help others', and on the 'lifestyle' factor, supporting previous findings [ 31].
Histology of leiomyosarcoma was the only factor with significantly negative impact on progression-free survival.
Recurrent situation at inclusion was the only factor with significantly negative impact on local control in univariate analysis.
