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On the car front, we're seeing a shift from traditional petrol-based cars to those powered by alternative energy sources like electricity, and cars that are significantly more connected, even to the point of being able to drive themselves.
The most striking feature of the network is the participation of primary nodes in interactions with at minimum two other nodes – indicating that this network is significantly more connected through microRNAs than one would expect by chance alone (p<0.01).
This analysis yielded a PIE score of 2.16, indicating that the CACN-1 network is indeed significantly more connected than a network of similar size derived from genes selected at random (P < 0.0001, Figure 2B).
However, all of the transcriptional regulators of innate immunity that were identified as hubs in the analysis above (JUN, NFKB1, RELA, STAT1, STAT3, EP300, CREBBP), were also identified by CHAT to be significantly more connected to 36 hpi DE genes than expected by chance.
In an attempt to provide the user with clues on how the expression modules are regulated, ENIGMA searches for 'regulators' that are significantly more connected to a module, through positive or negative coexpression edges, than expected at random (hypergeometric test, default FDR = 0.05).
By analyzing 24 genome-wide RNAi screens interrogating various biological processes in Drosophila, we found that RNAi positive hits were significantly more connected to each other when analyzed within a protein-protein interaction network, as opposed to random cases, for nearly all screens.
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Community-acquired infections (prevalence 13.9%) were significantly more often connected with MSSA, than MRSA (OR 0.42; 95%CI 0.24-0.68).
Bilaterally, the medial clusters were significantly more functionally connected to nodes of the default-mode network (see Fig. 6): namely, the bilateral medial PFC, the bilateral precuneus/posterior cingulate cortex, the ipsilateral lateral occipital cortex, the bilateral parahippocampal gyri, the bilateral subgenual cingulate cortex, the bilateral middle temporal gyrus.
AMERICANS are more connected now than ever.
Siamese twins could scarcely be more connected.
The world is getting more and more connected.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com