Haemoptysis was significantly more common in benign diagnoses (P<0.0001).
In the USG-FNA group, significantly more subjects had benign cytology results and significantly less number of subjects had inadequate smears compared to P-FNA group.
Detection of the intact E2 gene was significantly more frequent in benign lesions than in cervical carcinomas (P < 0.05, Fisher's Exact test).
Consistent with this marked acceleration of disease, histological examination of pancreata showed a significantly more rapid progression from benign to aggressive/destructive insulitis in anti-GITR-treated NOD mice as compared to controls (figure 1B).
Contrasted MRI disclosed significantly more lung nodules, both benign and suspicious, than noncontrasted MRI (p < 0.001).
Additionally, human prostate cancer cells express significantly more GRP78 than their benign counterparts, and increasing GRP78 expression correlates with recurrence and poor survival [ 17].
However, the combined approach of non-enhanced and SPIO-enhanced T2-weighted MR images together resulted in a significantly higher sensitivity as well as in significantly more accurate differentiation of benign from malignant lesions as compared with results from spiral CT images, non-enhanced T2-weighted MR images or SPIO-enhanced T2-weighted images alone[ 37 ].
One multicenter study of lung nodule enhancement on CT reported that malignant neoplasms were significantly more enhanced than granulomas and benign neoplasms, and with 15 HU or greater as the threshold, sensitivity for malignancy was 98% (167 of 171 malignant nodules), specificity was 58% (107 of 185 benign nodules), and accuracy was 77% 8.
Surprisingly, the most common variant, c.1676A > G (Gln559Arg; rs152451), which is predicted by CADD, Condel, PolyPhen2 and SIFT to be benign, was significantly more common in cases (19.9 % carried at least one non-wild-type allele) than controls (16.8 % non-wild-type) with a per-allele OR of 1.24 (95 % CI 1.09 1.47, p = 0.002, logistic regression).
