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"significantly misleading" is correct and usable in written English.
It refers to something that is greatly deceiving or giving false information. It can be used in various contexts, such as in advertising, news articles, legal documents, etc. Here is an example: "The company's advertisement was significantly misleading, as they claimed their product could cure all illnesses, when in reality it only had minor health benefits."
Exact(14)
It was significantly misleading – given that it suggested a fundamental breach of the Queen's constitutional obligations".
So, it concluded, "the manner in which the claims were presented was significantly misleading".
The press standards body also ruled that a front-page headline in the Sun claiming the Queen "backs Brexit" was "significantly misleading".
The Daily Star Sunday has been censured for printing a "significantly misleading" headline suggesting Britain's mosques were raising funds for terrorist organisations.
The newspaper had failed to take appropriate care in its presentation of the poll results and, as a result, the coverage was significantly misleading".
In Friday's edition of the paper, an article outlining the Independent Press Standards Organisation ruling said that the "manner in which the claims were presented was significantly misleading".
Similar(46)
Any error in hemodynamic assessment may significantly mislead surgical and other clinical treatment strategies.
However, it may significantly mislead the reader about the larger context of CaMKII in synaptic plasticity.
The FSA said the move marked a tough approach to levying financial penalties after the introduction of beefed-up rules which are expected to lead to significantly higher fines for misleading financial reporting.
However, participants in the Emphasized Details group (t(43) = 5.31, P < 0.001, d = 0.69) and participants in the Interim Test group (t(43) = 3.51, P < 0.001, d = 0.58) were significantly less accurate on misleading trials as compared to neutral trials.
Consequently, using the paclitaxel binding conformation or pharmacophore in the design phase for such significantly pruned agents would be misleading.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com