Sentence examples for significantly lower potency from inspiring English sources
Furthermore, in vivo skin prick tests showed that it has a significantly lower potency to induce cutaneous reactions than the mixture of recombinant wild type allergens and whole extract while, it had been preserved immunogenic properties.
Apparently, all compounds from the 1,4-dihydropyrimidinones series 14– 24 showed significantly lower potency against rat neutrophil elastase (RNE, Table 4).
The estrogenicity of the metabolites that were identified but not tested for hormonal activity cannot be ruled out; however, in general, conjugated BPA metabolites have significantly lower potency than that of the parent compound.
The utility of the OVX rat is limited by significant interspecies sequence variation (88% homology) in key residues within the active site of human and rat CatK enzymes [ 12]; inhibitors of human CatK have significantly lower potency against the rodent CatK enzyme to be reliably tested for bone effects in the rat or mouse model.
However, fluorescent conjugates 57– 64, containing bulkier rhodamine dyes, showed significantly lower potency or complete loss of COX-2 inhibitory activity with the exception of compound 58 (λex = 572 nm, λem = 595 nm), which displayed activity comparable to the 5- and 6-ROX conjugates.
23 Metabolites M1 and M4 formed by these pathways have significantly lower antiviral potency than EVG.
Two siRNAs were targeting other mRNAs (GAPDH and HuR), the third siRNA ('SSB 53)') targets another site within the same mRNA (SSB) but with significantly lower overall potency.
The indolyl-sulphonamide derivative 46 also showed improved selectivity compared to analogues without a targeting motif (see compounds 13– 25), although its potency is still significantly lower than other indolyl-sulphonamide quinols (see compounds 13– 25).
As is shown in Fig. 8C this is indeed the case, however, the potency of the response is significantly lower for these chimeras than for the native Ste2 receptor.
For all of the chemotherapeutic agents tested, the potency in the TSQ was significantly lower than that observed in the TSP (Table 1).
However, these low potency compositions rapidly precipitated leading to significantly lower AUCs (p < 0.05).
