The present study showed that the subjects who had complaints had significantly less stimulated salivary flow rate than those who reported no complaint.
Before the development of proteinuria, BPA-fed NZB/NZW mice produced significantly less ConA-stimulated IFN-gamma than did controls and displayed an average reduction of 50% in immunoglobulin G2a (IgG2antibodyody production from lipopolysaccharide (LPS -stimulated spLPS -stimulated0.05).
Primary tumour cultures from ovarian cancer patients also showed a variable response to MC. Fibroblasts from malignant, benign and non-neoplastic sources were significantly less effective in stimulating the clonogenic growth of responsive cell lines.
However, the growth of control cells was stimulated nearly 2-fold by DHT at optimal levels (0.1 μM), whereas arsenic-transformed CAsE-PE cells showed significantly less growth stimulation.
Nevertheless, NPY, and to a lesser extent PYY, were significantly less potent agonists for stimulating Y2/βarr2 BiFC than observed for Y1/βarr2 responses (19-fold difference comparing NPY EC50 values; P < 0.001).
DOI: http://dx.doi.org/10.7554/eLife.06633.010 During the stimulation period, ChR2-expressing mice spent significantly less time on the stimulated side of the chamber, and withdrew from that side with shorter latency and higher velocity than did photostimulated eYFP-expressing control mice.
OGR1 deficient mice in the mixed background produced significantly less peritoneal macrophages when stimulated with thioglycolate.
THP-1 KD cells secreted significantly less IL-β when stimulated with LPS and nigericin, demonstrating the efficiency of NLRP3 and ASC gene silencing (Figure 3B).
B-1P cells proliferate significantly less than B-2S cells when stimulated with various TLR agonists, including Pam3CSK4 (TLR-1/2), poly(I∶C) (TLR3), loxoribine (TLR7) and CpG (TLR9).
Interestingly, those patients who developed a second infection or died had significantly less IFNγ secretion from in vitro stimulated PBMCs than those who recovered uneventfully.
In contrast to this, the proinflammatory chemokine CCL7 did elicit a mild flux in 4% of cells, although this was significantly less than that seen in samples stimulated with opsonized E. coli (Fig. 7 D ; P<0.05).
