Exact(8)
Indeed, when the sequence conservation levels of target sites identified by the two methods were compared, Made1 related targets were found to be significantly less conserved, on average, than miRanda predicted targets (conservation scores: Made1 targets = 0.082±0.017 miRanda targets = 0.319±0.007; t = 11.27 P = 5.7e-29 Student's ttest).
For both PfGK and HsGK, codons in the extreme purifying selection category spanned the entire coding sequence, although the 5' and 3' ends were significantly less conserved overall, and this was also more pronounced in PfGK.
The new microRNA sequences described here demonstrate a reduced substitution rate from a neutral model (Figure 3D, grey), but are significantly less conserved than the population of known microRNAs.
Proteases were significantly less conserved than the whole set of annotated predicted proteins.
Precise function can be reliably transferred only if sequence identity is at least 40% [ 11]; structure is significantly less conserved when sequence similarity is less than 50% [ 12].
> -wrap-foot> Polarity, size, hydrophobicity and charge are all significantly less conserved between groups in putative SDPs than in the background.
It was also discovered that the LRR domains are significantly less conserved than the remaining domains of the LRR-RLK genes [ 55].
Typically, nucleotide sequences diverge much faster than amino acid sequences, and the first exons of RD genes are significantly less conserved than the runt domain itself, on which we based our phylogenetic analysis.
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