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These factors – taken together – significantly increase the challenges of dialysis [ 9, 10].
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"This new figure significantly increases the challenge we face in terms of the likely impact [of climate change] we should expect and also the effort we should put in to mitigate and adapt," said Martin Parry, a co-chairman of the IPCC's climate change impacts working group II.
Two and 3 days later the mice were intraperitoneally treated with SEB or PBS. Figure 7C-D shows that treatment with SEB was able to significantly increase the survival of mice challenged with T8.2 lymphoma (log-rank test, p<0.0001).
A second challenge is to significantly increase the productivity of rainfed lowland rice.
Obesity-induced insulin resistance and metabolic syndrome continue to pose an important public health challenge worldwide as they significantly increase the risk of type 2 diabetes and atherosclerotic cardiovascular disease.
The addition of AHL to the growth and challenge media did not significantly increase the acid resistance phenotype, suggesting that the basal level of AHL-independent SdiA activity is sufficient for acid resistance.
Pretreatment with the mixture of sub-therapeutic phenytoin and the ethanolic valerian extract (ValE PHT) significantly increased the latency to PTZ challenge to 310 ± 12 sec, around three times that latency of naïve fish, and significantly different from the latency in the ethanolic extract alone (p < 0.0001).
Compared with vehicle challenge, the LPS challenge significantly increased the number of neutrophils (p < 0.01).
Additionally, indomethacin challenge significantly increased the expressions of NOX-1, in which pantoprazole significantly attenuated the increased expression of NOX-1, suggesting that pantoprazole-induced HO-1 imposed anti-inflammatory actions under indomethacin.
Depletion of AMs during either allergen sensitization or challenge significantly increased the number of tissue leukocytes recruited to the lung in response to HDM exposure (Fig. 3A).
Treatment with 40 mg/kg berberine significantly increased the survival rate of mice challenged with Salmonella typhimurium (LT2), but berberine show no effects in bacteriostasis.
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