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The combination of Presepsin and PCT significantly improved specificity and PPV (Table 4).
However, indexing significantly improved specificity and accuracy of visual scores, such that indexed visual scores were statistically equivalent to all other methods.
CONCLUSION: The multivariate statistical algorithm based on both types of spectral inputs at 337 nm excitation has a similar sensitivity and significantly improved specificity relative to colposcopy in expert hands.
In contrast, the search parameters used for Searches B and C yielded only modest reductions in sensitivity compared with Search A but significantly improved specificity (Figure 2).
The results showed that the developed cELISA demonstrated significantly improved specificity and good sensitivity.
The new 2014 Refined Criteria significantly improved specificity (94.0%) across all ethnicities compared with the 2012 Seattle Criteria and 2010 ESC recommendations (87.5% and 76.6%, respectively).
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The assay significantly improves specificity over culture, but sensitivity of sodC compared to culture is difficult to determine due to the lack of culture-positive clinical specimens received.
The authors found that T2-weighted images yielded a high specificity and negative predictive value (93.1% and 94%, resp ., and addition of DWI was able to significantly improve specificity and positive predictive value, which remained limited (70%).
Thus, using the S19 score to predict quality of RNAi lines significantly improves specificity, and we therefore discarded lines with a score below or equal to 0.85 from our analysis.
The kinase inhibitor cocktail used in this paper was adapted from previous work that showed that this inhibitor combination significantly improves specificity (reduce nonspecific phosphorylation by interfering kinases by 75%) and does not inhibit the kinase that is being assayed for.
With respect to both the disease control and objective response endpoints, use of this multi-gene classifier in addition to KRAS status significantly improves specificity and PPV when compared with a patient selection based on KRAS status alone, but with a slight decrease in sensitivity.
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