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vaccination of MERS-CoV RBD-Fc induced systemic humoral immune responses comparable to those induced by s.c. vaccination, including neutralizing antibodies, but more robust systemic cellular immune responses and significantly higher local mucosal immune responses in mouse lungs.
The windward reaction zone is much thinner in the near field, while also exhibiting significantly higher local and global heat release than the much broader reaction zone found on the leeward side of the jet.
Patients who had a lower median perfusion rate had a significantly higher local failure rate.
Patients with high density of TAMs in tumor invasive front (TIF) showed significantly higher local and overall tumor recurrence (both ρ < 0.05).
However, in an unplanned subgroup analysis, they found that there were significantly higher local control rates for IA treatment for large (>30 ml) lateralised tumours.
High nuclear and tumor EGFR protein levels were associated with significantly higher local recurrence rates and inferior disease-free survival and OS times.
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We found that IN, p6, PR, Rev, reverse transcriptase (RT), Vif, Vpr interact with host proteins of a significantly high local connectivity.
When we included WTP per QALY estimates based on predicted values, the median amount remained significantly higher for local reactions vs. septic arthritis (p = 0.019), local reactions vs. toxic shock syndrome (p = 0.044), systemic reactions vs. strep throat (p = 0.010), systemic reactions vs. septic arthritis (p = 0.008), and systemic reactions vs. toxic shock syndrome (p = 0.009).
In patients with AMI, the fold change in TLR4 with HSP70 stimulation was significantly higher in local samples than in systemic samples, whereas there was no significant difference between local and systemic samples for TLR2.
Two studies showed statistically significantly higher actuarial local recurrence rate in the short margin group compared to the long margin group.
In patients with AMI, the fold change in supernatant TNF-α levels with HSP70 stimulation was significantly higher in local samples than in systemic samples.
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