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In these studies, serotype 6B has a significantly higher fold range than 9B (P<0.0001, Z = 4.18, Wilcoxon signed rank test).
NRF1 was significantly higher (fold change = 1.23, p = 0.0115 for SC versus SNC; and fold change = 1.54, p = 0.0084 for SC verse NS, by t-test).
However, the 80 µg AMA1+CPG group was not significantly higher (fold change of 1.15, 95% CI 0.78 1.81, p = .4194) than the 20 µg AMA1+CPG group on Day 42.
It was up-regulated at the inoculation site at 48 and 72 hai across all the resistant and susceptible lines, however, significantly higher fold changes were observed in the R group at 48 hai.
We found that the expression of miR-125a-5p miR-125a-5p miR-125a-5pcandly higher (fold changes=2.84 and 2.39, respectively) in the imatinib-resistant tumours (P=0.032 and P=0.041, respectively; t-test).
As shown in Figure 8 and Table 3, the expression levels of Col1a1, Col1a2, P4ha3, Plod1, Plod2, Lox, and Loxl2 were significantly higher (fold change > 2.0, P < 0.05) in fibroblasts and myofibroblasts of bleomycin-injured lungs than in fibroblasts of saline-treated lungs.
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By qPCR, we found significantly higher fold-change values in the injected BM compared with i.v. injection (P=0.0087).
To identify root functions and processes that are down-regulated during the development of FRs into SRs, we looked into genes represented by contigs that exhibit significantly higher fold-change expression in FRs compared to ISRs.
Although the Her2+ sample did not show the opposing pattern of expression, one isoform had the significantly highest fold change of all the samples.
Moreover, many of these transporters were induced at significantly high fold changes, such as slr2131 encoding a RND multidrug efflux transporter up-regulated 12.87 fold at 72 h, and sll1428 encoding a probable sodium-dependent transporter up-regulated 32.0 folds.
Red, fold change significantly higher; green, fold change significantly lower than control (p < 0.05 by ANOVA); light green, fold change slightly lower compared to controls; light red, fold change lightly higher than control (0.05 < p < 0.1 by ANOVA).
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