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Eastern European countries, mostly because of the Chernobyl accident, may have significantly higher exposure.
The simulations suggest that doses of DCU that are higher than 30 mg/kg delivered using nanosuspension will not provide significantly higher exposure in vivo.
Morphology-confined crystal growth of (Y0.95Eu0.05 2O3 was observed from the microplates, yielding a significantly higher exposure of the (4 0 0) facets at elevated temperature.
Exposure on off-street facilities is higher than at a park, but lower than on-street riding – with the exception of a path through an industrial corridor with significantly higher exposure.
Coadministration of primaquine with dihydroartemisinin-piperaquine resulted in significantly higher exposure, higher Cmax, lower V/ F, and shorter t1/2 of both primaquine and carboxyprimaquine.
Pregnant women had a significantly higher exposure (AUC0 24) and longer TMAX after the first dose compared with non-pregnant women (Table 3).
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Personal activities, including refueling and commuting, contribute significantly higher exposures but last for only a small portion of the 24-hr time weighted average.
"The effects shown in this paper occur at significantly higher exposures; thus, at present exposure levels there seems to be a margin of safety," says Jerry Heindel, a health scientist administrator at the National Institute of Environmental Health Sciences, which supported the study in part.
The elimination clearance of primaquine (P = 0.013) was lower in combination with pyronaridine-artesunate than when primaquine was administered alone, resulting in significantly higher exposures to primaquine (AUC0 last, P = 0.013 and AUC0 ∞, P = 0.015).
More specifically, children in the 10th percentile of the distribution had significantly higher exposures during the first 17 weeks of pregnancy compared with children in the lower 90th percentile of the distribution.
Women who reported unintended pregnancies had significantly higher exposures to physical/sexual IPV, sexual abuse, and controlling behavior by a partner than those not reporting unintended pregnancies (Table 1, p < 0.05).
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