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In the presence of stroma a 70 kDa rhodamine-dextran was significantly excluded from the lumen of spheroids.
Bagg albino derivates mice were highly significantly excluded from the most resistant cluster (p = 7×10−7).
The Japanese and New Zealand strains were significantly excluded from the most susceptible cluster and enriched in the intermediate survival cluster (p = 0.0001 and p = 0.0006, respectively).
Swiss mice and Castle's mice were significantly enriched in the most susceptible cluster (p = 1×10−5 and p = 3×10−5, respectively) while significantly excluded from the most resistant cluster (p = 0.002 and p = 0.004, respectively).
The "species topologies" were significantly excluded also if we compared topologies rooted by Trichomonas and Escherichia, although the significance was lower (p = < 0.001).
This result suggests that the rodlike CFP-10 with dimensions of 1.5 × 6 nm was not significantly excluded by nanopores larger than 3.9 nm.
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The most common comorbidities were cardiocerebrovascular (67.3%), pulmonary (42%), chronic kidney disease (CKD) (32.5%), diabetes (27.9%), all of which increased significantly (excluding CKD).
This clearly indicates that even in its most compacted form, chromatin is not dense enough to significantly exclude proteins smaller than 100 kDa nor impede their diffusion, in good agreement with results obtained by single molecule tracking with high-speed fluorescence microscopy [47].
Net myocardial lactate uptake also increased significantly, excluding myocardial ischaemia.
Overall, these subcohorts did not seem to differ significantly, excluding period effect as a confounder.
This because it seems a virus cannot easily mutate these targets to escape, as our statistics significantly exclude free co-mutations within those targets.
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