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"significantly difficult" is a correct and usable phrase in written English.
You can use it to describe something that is much more difficult than normal or expected. For example, "The problem was significantly difficult, and it took a lot of research to figure out the solution."
Exact(21)
However, unfortunately traffic matrix is significantly difficult directly to attain.
In addition, the prior probability distribution is required, which is significantly difficult to be obtained.
The placement was significantly difficult in patients with history of tricuspid ring annuloplasty.
Unfortunately, limited by current technologies, it is significantly difficult to acquire the exact traffic matrix.
However, it is significantly difficult to obtain the accurate end-to-end network traffic.
The two-phase flow macro-properties of shale are significantly difficult to be measured in the laboratory.
Similar(39)
This makes passing major reforms significantly more difficult.
But finding a tour gets significantly more difficult the more points you add.
However, it would make his path to the nomination significantly more difficult.
But it is unlikely that things will get significantly more difficult than they have done already.
Without the underpinning of these key advertising categories, maintaining sales becomes significantly more difficult, as today's publishers have found..
More suggestions(15)
slightly difficult
dramatically difficult
considerably difficult
vastly difficult
appreciably difficult
noticeably difficult
markedly difficult
significantly complex
significantly challenging
significantly different
much difficult
fundamentally difficult
energetically difficult
significantly complicated
distinctively difficult
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com