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Significantly different correlations are shown in italics.
Both methods revealed similar results for libraries possessing significantly different correlations.
The five most significantly different correlations between normoxia and hypoxia are shown in Table 2.
Daggers indicate significantly different correlations between groups for a particular region of interest (P < 0.05, two-sided).
In the assessment of diurnal regulation by correlation to PER1, a high degree of correlation among the three states was observed, indicating that the largest effect on the transcriptome is the time of day and not any other perturbations; nevertheless, there were ~500 genes with significantly different correlations to PER1 among the three states.
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First, pairwise comparison shows that 10 pairs of categories exhibit significantly different correlation coefficients (supplementary table S2, Supplementary Material online).
However, as only one item of the Emotional score produced a significantly different correlation, the results were considered to be satisfactory.
Most metrics for the individual groups had significantly different correlation coefficients from the baseline method (P < 0.05, Hotelling Williams test) (supplementary fig. S1, Supplementary Material online).
The significantly different correlation value distributions between directly and indirectly linked metabolites barely provide a good quantification of the actual discrimination accuracy of this feature.
More than 25 (out of the 30) learned metrics showed significantly different correlation coefficients for the Proteobacteria, Firmicutes and Actinobacteria (Hotelling Williams test, P < 0.05) (supplementary fig. S1, Supplementary Material online).
Taken together, our results indicated that mRNAs, intergenic lncRNAs, and antisense RNAs each have significantly different expression correlation properties with neighboring loci.
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