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None of the groups tested significantly destabilized the duplex.
In the case of GBP, the apo structure is significantly destabilized (Δ T m = 39 K).
Thermostability studies also revealed that peptide insertion significantly destabilized the Trx scaffold by ∼ 27 °C.
Instead, the base pairing of 2-amino-Adap with dG was significantly destabilized compared with that of Adap with dG, resulting in improved selectivity for 8-oxo-dG in the human telomere DNA sequence.
In Afghanistan, a long-revived Taliban can't be defeated, while neighboring Pakistan, with its own Taliban movement, has been significantly destabilized.
By modulating multiple functional immune cell types and their corresponding cytokines, EPO therapy transformed a significantly destabilized autoimmune process in EAE animals into one of relatively normal immune status.
Similar(40)
As described previously by Vinson and by Doig, phosphorylation of serine here was significantly destabilizing with respect to α-helicity, with the destabilizing effect of phosphorylation being larger than the stabilizing effect observed at the N-terminus.
Saddling current policyholders with soaring premiums will lead to an exodus from the program that will significantly destabilize it.
Especially when soluble carbonates are present, reductions in the pore solution pH, which often accompany ingress of sulfates, significantly destabilizes calcium monosulfoaluminate and accelerates AFt growth.
Replacing one ferrocene amino acid unit by the organic α-amino acid glycine at the C-terminal end (Fca → Gly) significantly destabilizes the secondary zigzag structure facilitating denaturation by DMSO.
From UV melting studies we showed a position dependent effect of UNA modifications such that quadruplexes with UNA modified loops are further stabilized whereas UNA modifications in stem of the G-quadruplex significantly destabilize the structure.
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