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Significantly, deletion of any part of the minimal required region led to a strong inhibition of BM2fluc synthesis, suggesting that the entire TURBS is required for efficient termination-reinitiation on the segment 7 RNA (Figure 1A).
Most significantly, deletion of omcZ greatly decreased power production and omcZ-deficient cells did not adapt to overcome the loss of omcZ, even after relatively long incubations in current-harvesting mode.
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Similarly, we detected significantly larger deletion spans in the adaptive recovery populations compared to spontaneous deletions occurring under mutation accumulation conditions (Wilcoxon two-sample test, Z = −2.4, p = 0.016, Fig. 3b).
Isolates from Suriname and French Guiana had a significantly smaller deletion in RD12 (35.2 kb).
In most of the lines, however, eye pigmentation increased significantly after deletion of the UAS promoter Ey e YW).
Apoptosis was not detected in wild-type fiber cells at P3, but cell death increased significantly after deletion of Acvr1 (Fig. 1F).
This latter issue is of particular importance since the severity of the spermatogenic impairment defect in the male progeny is impossible to predict, and most significantly, partial deletions have been linked to an increased propensity for the more deleterious complete AZFc deletion.
We find that depleting SETD2 generates a mutation signature resembling RAD51 depletion at I-SceI-induced DNA double-strand break (DSB) sites, with significantly increased deletions arising through microhomology-mediated end-joining.
We found that allelic loss of chromosome 1p and 19q was higher in oligodendrogliomas than in other diffuse gliomas and that for anaplastic oligodendrogliomas, younger patients exhibited significantly more deletions than older patients (>60 years of age).
Meanwhile, RBP-J deletion significantly hampered macrophage infiltration and activation in fibrotic kidney, although their proliferation appeared unaltered.
iNOS deletion significantly reduced FFA and cholesterol concentrations in wild type and ob/ob mice (p<0.01).
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