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"significantly compromise" is a correct and usable phrase in written English.
It means to have a significant impact on or to greatly reduce the effectiveness or integrity of something. Example: The security breach significantly compromised the company's sensitive information, leading to a major data leak.
Exact(59)
If left unchallenged, the proposals could significantly compromise safety and the lives of mothers and babies in England".
The judge, Donna R. Merris, found that the department had not shown a turban would significantly compromise public safety and that there was no evidence the department had "seriously considered" the agent's request for accommodation.
In reply, Mr. Fitzgerald wrote Tuesday that he had considered his office's legal obligations and the special sensitivities involved, concluding that "producing those items at this time could significantly compromise the ongoing criminal investigation".
Investigators found that "BPD seriously and systematically under-investigates reports of sexual assault, and the sexual assault investigations it does conduct are marked by practices that significantly compromise the effectiveness and impartiality of its response to sexual assault".
The influence of such gradients on the microbial metabolism can significantly compromise optimal bioreactor performance.
This porosity variation can significantly compromise the comparison of the thermoelectric properties of these samples.
All of these disadvantages significantly compromise the performance of LSWT-PCNN.
Daily setup variations can therefore significantly compromise the ultimate precision of idealized H&N IMRT delivery.
Such systems are vulnerable to thermal stratification, which can significantly compromise performance.
The presence of a perforation is known to significantly compromise the outcome of endodontic treatment.
Uniaxial tensile testing indicated that decellularisation did not significantly compromise the ultimate tensile strength of the tissue.
More suggestions(15)
significantly deal
greatly compromise
markedly compromise
noticeably compromise
appreciably compromise
significantly harm
significantly balance
much compromise
further compromise
considerable compromise
significantly jeopardize
significantly compromised
significantly jeopardized
adversely compromise
made compromise
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com