"significantly challenged" is correct and usable in written English.
It is often used to describe a situation or person that faces significant obstacles or difficulties. Example: "The small town's economy was significantly challenged by the closure of the main factory, leaving many without jobs."
The capacity of African communities to cope will be significantly challenged".
Such difficulties have been significantly challenged the design of effective handcraft features as well as robust detectors.
The studio will provide students with examples of projects that have significantly challenged existing domestic models, thus questioning the very ideological core of domestic space.
According to the DfE, the Tef panel will award gold to a university if its courses offer "outstanding levels of stretch that ensures all students are significantly challenged to achieve their full potential".
Such methods can be significantly challenged by modern analytical instrumentation where the baseline tends to drift, peaks of interest may have a low signal to noise (S/N) ratio, and no well-defined reference peak shape is available.
Silver grades will be awarded to universities offering courses with "high levels of stretch that ensures all students are significantly challenged," while bronze will go to universities where "provision is of satisfactory quality … however, the provider is likely to be significantly below benchmark in one or more areas".
She suggests that many theatre-makers "try on those tropes" without significantly challenging both the theatrical and political status quo.
(Amazon chief executive Jeffrey P. Bezos also owns The Washington Post). Nobody's been able to significantly challenge Apple in smartphones.
Due to salient features of sensor networks, the security design for WSN is significantly challenging.
How to inhibit the calcification of elastin-based scaffolds, but maintain their good biocompatibility, still remains significantly challenging.
Surprisingly, important recent research defined growth promoting capabilities of PML, which significantly challenges the notion of a 'classic' tumour suppressor.
