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Although the reason why the single bortezomib regimen is not significantly active in clinical trials might be explained by the possibility of the activation of multiple drug resistance pathways in heavily pretreated populations, particularly those previously exposed to anthracycline [ 16], alternative mechanisms might also confer sensitivity to bortezomib in patients with breast cancers.
Compound 9i was found to be significantly active in this assay and also induced cell death by apoptosis.
The majority of cytokinin derivatives were significantly active in both Amaranthus as well as in tobacco callus bioassay and almost inactive in detached wheat leaf senescence assay.
Immunoblot analysis demonstrated epidermal C/EBPβ levels were similar in the two genotypes indicating the CreERtam fusion protein was not significantly active in the absence of 4OHT treatment (Fig. 1C).
ASA (200 mg/kg; 52.2% inhibition) and MOR (98.76% inhibition) were significantly active in first phase (p < 0.05).
It was found that turmeric volatile oil was significantly active in removing sputum, relieving cough and preventing asthma.
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Two of the three activations were located within significantly active clusters in the Hated face>Neutral face contrast, while the third one was located in close vicinity of the active cluster in the right premotor cortex.
The two sets of edge weights were then compared (see Methods for further details) to find the significantly active edges in the viral oncogene-associated regulatory network (Fig. 6a).
While cathepsin S is significantly more active in all OA sera than cathepsin B, only cathepsin B was significantly enhanced in sera of early OA versus late OA patients.
"However, if management and the board fail to make progress, Trian may decide to become significantly more active in evaluating its alternatives as a large shareholder".
Some species were significantly more active in weedier fields but others preferred more open ground.
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