This presents a significant window of opportunity for preventing or slowing tumour growth.
Gestation and the first 2 postnatal years (the first "1,000 days"; http://www.thousanddays.org) are the time when children's growth in LMICs falls most rapidly below international reference values (5) and, hence, provide a significant window of opportunity for improved infant survival, cognitive development, and adult economic status (6, 7).
SweepFinder identified several significant windows of composite LR for most cases of SNV and microsatellite selection under both demographic scenarios.
The statement on Monday, which provides the first significant window into the agency's timeline for derivatives rules, is aimed at alleviating some of the ambiguity.
These distributions of differences were used to determine an RPKM cutoff that resulted in 100 significant windows in the sample-input comparison for every one significant window in the input-input comparison, thus a 1% FDR.
The most significant window on MSP-Best analysis was at 1q23.2-q25.3 (p = 1.94E-03), jundernder LK-suggestive criteria, providing nominal evidence for linkage within the window.
The broken horizontal line in each panel is the genome-wide significance threshold for each contrast (significant windows red).
For 500-kb windows, we do not find an excess of nominally significant windows beyond that expected by chance, and for 100-kb windows, we actually find a significant deficit of windows with excess YRV genes (500-kb windows: 8/244 significant tests, χ2 = 1.522, df = 1, P value = 0.217; 100-kb windows: 26/1,208 significant tests, χ2 = 20.6232, df = 1, P value = 5.59 × 10−16).
Most of the genes are outliers for more than one statistic, and show multiple significant windows.
Evidence of the positive selection was assumed for windows in the extreme 2.5% of the empirical distribution which resulted in 127 significant windows (Additional file 1, Table S2).
