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Still, Bonds's significant weight gain (the factor that has convinced many fans that he used steroids) does not necessarily prove his own state of mind.
But the side effects of lupus medicines include significant weight gain, blurred vision and diabetes, and many patients have a hard time sticking to the regimen, he said.
Tom Cruise is planning a significant weight gain to play a 20-stone American pilot who trafficked drugs and guns for the Medellín cartel in the 1980s-set biopic Mena, reports the New York Post.
"Those are large reductions in energy expenditure," Dr. Archer said, and would result, over the years, in significant weight gain without reductions in caloric intake.
A five-week study showed that sleep disruption decreases insulin secretion, increases blood glucose levels and slows metabolism enough to lead to significant weight gain.
Depo-Provera has other serious risks and adverse effects, including loss of bone density in young women, significant weight gain and increased depression.
They showed that after adjusting for age and other factors, the men who ate breakfast were 13 percent less likely to have had a significant weight gain.
Long-term therapy may result in clinically significant weight gain.
Atypical antipsychotics have been reported to cause significant weight gain.
Olanzapine was well tolerated, though significant weight gain was observed.
Five subjects discontinued prematurely due to adverse events; two in the CIN group with significant weight gain, and three in SV with significant weight gain and sever tremor.
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