Sentence examples for significant variant in from inspiring English sources

In general, by applying this method, the most significant variant in overlapping LD blocks were considered as the true association of a gene.

In analyzing this batch of samples, we assessed all the positions across the viral genome in which there was a significant variant in the alternating passage sample that had cycled through mosquito cells, which was not found in any of the other samples (that encountered only mammalian cells) above a rate of 0.001.

To test the hypothesis that some functionally significant variants in the gene encoding member A3 of the ATP Binding Cassette family (ABCA3) are not detected using exon-based sequencing approaches.

The most significant variants in the regions were the rs864745 in intron 1 of JAZF1, rs12779790 between CDC123 and CAMK1D, rs7961581 between TSPAN8 and LGR5, rs7578597 in exon 24 of THADA, rs4607103 near ADAMTS9 and rs10923931 in intron 5 of NOTCH2 [6].

No statistically significant variants in mitochondrial genes or in mitochondrial heteroplasmy were identified.

Combining the results from all previous studies of genetic variants that may cause urinary symptoms in men, we found significant variants in five genes.

The emerging picture suggests that some functionally significant variants in CHEK2 are able to predispose cells from a wide distribution of organs to an elevated risk of cancer.

The proportion of overlapping significant variants in 100-kb windows was even lower 20-300%) when using different genetic maps but the same GWAS markers.

Similar results for rs17088251 were reported by Shifman et al. (2008), where it is among the top 1000 most statistically significant variants in AJ females in a study of 500,000 SNPs.

We have recently described strongly associated, rare, functionally significant variants in the complement factor H gene (CFH) (6, 7), further suggesting that impaired complement regulation is central to the pathogenesis of AMD (7, 8).

While evidence is emerging that intellectual disabilities might be widely attributable to de novo mutations (41), cases of the high-functioning ASD may rather be attributable to co-inheritance of subtle, yet functionally significant variants in respective genes.