Exact(6)
On univariate analysis, statistically highly significant unfavourable risk factors for the brain metastasis-free survival were negative ER status, negative PR status, and triple negative tumor subtype.
Laudanski et al. showed that TP53 mutations and p53 overexpression were significantly correlated with poor survival in NSCLC; however, in a multivariate analysis, only the presence of TP53 mutations remained an independent, significant unfavourable prognostic factor for survival [ 15].
Laudanski et al. also showed a significant association between serum p53Abs and poor survival in NSCLC patients, even though in a multivariate analysis only the presence of TP53 mutations remained an independent, significant unfavourable prognostic factor for survival [ 15].
The presence of a CSF protein level over 0.6 g l-1 at diagnosis was found to be the most significant unfavourable prognostic factor in univariate analysis and had not previously been reported.
Univariate analysis of potential prognostic factors revealed that low expression of GalNAc-T3 was the only statistically significant unfavourable prognostic factor in overall NSCLCs (hazards ratio, 2.04; P=0.03) and in nonsquamous cell carcinomas (hazards ratio, 2.70; P=0.03).
In agreement with our study, a negative hormone receptor status has been identified as significant unfavourable factor for the probability of developing brain metastases in a study of 215 metastatic breast cancer patients [ 18].
Similar(54)
Although multivariate analysis demonstrated that the presence of lymph node metastasis was a significant independent unfavourable prognostic factor, this result suggests that tumour-infiltrating CD8+ T cells may not only locally but also systemically suppress metastasis in lymph tracts.
To distinguish these meanings we use the terms "statistically non-significant" and "unfavourable," respectively, and have attempted to clarify the meaning when the more general term "negative trial" was used by interviewees.
In addition to under-publication of statistically non-significant or unfavourable results, other forms of publication bias were mentioned, namely biases based on the type of research undertaken or its topic; the geographical origin of the research specifically studies from the developing world; and the standard of reporting particularly from non-native English speakers.
A study was called respectively, 'positive' or 'negative' when COX-2 increase was identified as a significant favourable or unfavourable prognostic factor for survival.
Significant relationships linking unfavourable CV profiles to body fat distribution measures, beyond BMI, have been observed in adults since the pioneer work of Vague.
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