Sentence examples for significant underlying disease from inspiring English sources

Comorbidity was frequent as would be expected in seriously unwell and older patients, and 87.9% of patients had significant underlying disease.

Patients were excluded if they refused consent, had evidence of worsening or complicated disease, had inability to swallow oral medication, had a history of significant underlying disease, had hypersensitivity to either of the trial drugs, or were pregnant or lactating.

The Food and Drug Administration FDAA) defined cSSSIs as infections of the deeper soft tissues, involving surgical intervention or a significant underlying disease state that complicates the response to treatment.

Significant underlying disease was defined as a medical history of diabetes mellitus, liver cirrhosis, malignancy, and congestive heart failure.

Most patients (70%) had no significant underlying diseases.

Baseline demographics, clinical characteristics, and significant underlying diseases are summarized in Table  1.

We found that the patients were moderately young, and mostly without any significant underlying diseases 16.

ARDS, APACHE II and the absence of significant underlying diseases on admission independently predicted the evolution to chronic critical illness.

Furthermore, in contrast to many studies from other countries, the clear majority of patients were moderately young and without significant underlying diseases.

A total of 53 patients (70%) had no significant underlying diseases (Charlson index score, 0); only 1 patient was known to have HIV infection.

Included in the group with Charlson index scores ≥2 were 5 patients with malignant diseases, 3 with moderate to severe liver diseases, 1 with renal disease, and 5 with ≥2 significant underlying diseases.