Although our patient had significant underlying conditions this case of meningitis was mild and had most of the typical features of "spontaneous" enterococcal meningitis (community-acquired infection, severe underlying diseases, and immunodepression).
Interestingly, patients with significant underlying conditions at baseline had an apparent large benefit with DrotAA and therefore are not expected to have positively influenced the second part of the trial.
There were 9 deaths among the 30 infants in the study (30%), all in infants with significant underlying conditions (7 with congenital heart disease and 2 with trisomy 21).
The following patients were ineligible: (i) distant metastases, (ii) prior chemotherapy or RT, (iii) significant underlying medical condition(s) that may be aggravated by the study treatment, (iv) conditions associated with the inability to swallow, tolerate or absorb oral medication.
Patients with significant underlying medical conditions were excluded.
Palivizumab may also be prescribed for patients with significant underlying medical conditions such as congenital airway anomalies, neuromuscular disease, immunocompromise, and Down syndrome, if they are considered at high risk of serious sequelae from RSV infection [ 2, 11, 37].
aSeverity of illness is based on modified McCabe criteria (23): 1, severe underlying coexisting chronic condition at imminent risk of death; 2, significant underlying coexisting chronic condition, not at imminent risk of death; 3, no significant underlying coexisting chronic condition.
We further demonstrated that inflammatory patients did not recover muscle strength and fatigue resistance during hospitalization despite adequate treatment of the underlying condition and a significant decrease in inflammatory markers.
The centers now discourage prescribing Tamiflu to healthy people as a preventive measure except in limited situations — for instance, to people with an underlying condition who have had significant exposure to the virus.
Although the condition is entirely preventable, malnutrition is a significant underlying factor in more than half of the deaths of young children in these countries [ 1, 3].
