Moreover, the agencies are likely to face "significant and unavoidable hurdles" in maintaining staffing levels because half of the employees in critical jobs are eligible to retire in the next five years, the study found.
However, because of the high complexity of cell metabolism, the identification and optimization of rate-limiting metabolic pathways for improving the product yield is often difficult, which represents a significant and unavoidable barrier of traditional in vivo metabolic engineering.
The tribe cited among other concerns "significant and unavoidable impacts and damage" to treaty rights reserved in the 19th century to fish at its "usual and accustomed" areas.
The oil and gas agency also released its environmental impact report that concluded fracking could have "significant and unavoidable impacts" on a number of fronts, including air quality, greenhouse gas emissions and public safety.
Apart from the populations not surveyed outlined in Methods, one other significant and unavoidable omission will be caregivers who themselves have died between relinquishing the caregiving role and the survey being performed [ 23].
Michel Salomon, a spokesman for the Air France branch of the union, the Confédération Française Démocratique du Travail, acknowledged that the current economic situation had left Air France in "fragile" health, and that significant reductions were unavoidable.
Holidays for pupils in term-time should only be granted in circumstances that are "rare, unavoidable, significant and short", says a head teachers' union.
In addition, the proposed controller incorporates a filtered integral action which allows to carry out a robust compensation of the state and output step disturbances, as well as a significant reduction of unavoidable measurements noises.
The multiple comparisons problem is significant, but is unavoidable in full-molecule coevolutionary analyses.
Perforation of the oesophageal wall was an unavoidable significant toxic effect of treatment for T4 disease.
