These data support the idea that the limited amino acid sequence similarities found between three diverse classes of cGMP-binding proteins are significant to the function of AQP1 as a cGMP-gated ion channel, and provide direct evidence for the involvement of the AQP1 C-terminal domain in cGMP-mediated ion channel activation.
Disulfide bonds are associated with the folding and stability of proteins and as such are significant to the overall function of that protein [ 43].
These grass-dominated areas may be significant to the overall catchment carbon functioning as they are often high in soil organic matter and elevated biological productivity due to the availability of agricultural nutrients.
These were named by experts as significant barriers to the functioning of individuals with ADHD (e.g. "cognitive overload", "emotional overload", and "noisy work environment").
In conclusion, the IGF system is significant to uterine function and the synthesis of these growth factors in the postpartum uterus indicates a role in uterine involution.
We present data from the Reproductive Health Voucher Programme in Yemen to show that during 2014, when the conflict was worsening and public facilities faced significant challenges to keep functioning, the vouchers enabled women to continue accessing quality maternal newborn health services.
Other significant categories belong to the functions of metabolism, cell cycle, protein fate, protein with binding functions, cellular transport, cell rescue, biogenesis of cellular components and subcellular localization.
In all our runs, parameter ϵ is set to 10 − 5, which was shown to be significant to minimize the objective function.
Either way, while these genes may not constitute direct targets of miR-181b, they are still significant to understanding its function in the context of specific biological environments.
There are no significant restrictions to the utility function other than having to return an integer value.
