Sentence examples for significant technical problem from inspiring English sources

When studying in vitro brain slices, rapidly applying multiple agonists, antagonists, drugs, or modulatory compounds is a significant technical problem.

Although amounting to a very small fraction of the sewage by weight, the nature of these impurities and the large volumes of sewage in which they are carried make disposal of domestic wastewater a significant technical problem.

There are significant technical problems related to this approach.

Under these conditions, a number of significant technical problems may arise as a result of the smaller geometry.

This manifests itself in a lack of support infrastructure and in a weak monitoring and maintenance program, which in turn give rise to significant technical problems.

Many significant technical problems have been overcome during the lengthy development history and large benefits have been predicted, however, the realization of these benefits through to production applications in the aerospace sector has to date been limited.

"It encountered significant technical problems … [and] struggled with a different contractor". The first replacement GPS satellite was due to launch at the beginning of 2007, but has been delayed several times and is now scheduled to go into orbit in November this year – almost three years late.

The production of such fluids involve significant technical problems and high economic costs that can make non-profitable investment.

It said its engineers had overcome two significant technical problems that had restricted the transfer of data at well below its theoretical limit of 4.6Gbps.

This work has not encountered significant technical problems, but the improved cultivars have not always proven to be acceptable to Japanese farmers or consumers.

And Cover Oregon and the Maryland Health Connection are among a handful of state-run exchanges with significant technical problems.