Sentence examples for significant systemic toxicity from inspiring English sources

The in vivo study of Dox and Fu biodistribution showed that high Dox and Fu concentrations were maintained in the target tumor only, while distribution to normal tissues was not observed, indicating that Dox and Fu concentrations below their toxic plasma concentrations should not cause significant systemic toxicity.

Cisplatin (CDDP) is an effective anticancer agent for many solid tumors but has significant systemic toxicity limiting its use in many patients.

Compared with saline group, the inhibitory rates of DPM@PL against tumor volume and lung metastasis were about 81% and 92%, respectively, and it didn't produce the significant systemic toxicity.

At last, HRP RGD NPs showed high biocompatibility and no significant systemic toxicity in vivo over 35 days treatment.

Intratumoral injection of PEG-[64Cu]-CuS at 7.4 MBq/mouse significantly delayed tumor growth compared to the non-treatment control (p < 0.0053), while no significant systemic toxicity was observed.

Based on these results, HRP RGD NPs were used in an in vivo anti-cancer study and demonstrated the best tumor growth suppression effect of all tested drugs with no relapse, high in vivo biocompatibility, and no significant systemic toxicity over 35 days treatment.

Larazotide acetate was not detected in the plasma after supra-therapeutic doses, and no significant systemic toxicities were observed.

64 This procedure was repeated on treatment days 1, 5, and 8. Intratumoral IL-12 expression assessed by enzyme-linked immunosorbant assay (ELISA) increased with increased plasmid dose, and no significant systemic toxicities were noted even at the highest plasmid dose tested.

Importantly, animals treated with lipo-CpG did not exhibit signs of significant local or systemic toxicity, changes in body weight or ambulation, suggesting a lack of toxic side effects on healthy tissue that might be exposed to the lipid conjugate.

No significant systemic or intracranial toxicity was encountered.

Mitoxantrone is effective in the treatment of malignant pleural effusion secondary to ovarian cancer without causing significant local or systemic toxicity.