Infants below 6 months of age with a significant heart disease and Down syndrome or other chromosomal abnormality or known immunodeficiency or significant syndrome.
In clinical practice, however, with a wider range of patients than are eligible to take part in clinical trials, the rate of permanent discontinuation due to HFSR is often higher, emphasizing the need for optimal recognition, prevention, and management of this clinically significant syndrome.
"Disorders due to addictive behaviours are recognizable and clinically significant syndromes associated with distress or interference with personal functions that develop as a result of repetitive rewarding behaviours other than the use of dependence-producing substances," writes the WHO.
There were too few H3N2 cases to identify significant syndromes.
CI, confidence interval; GI, gastrointestinal; MCTD, mixed connective tissue disease; NS, not significant; overlap syndrome, overlap with systemic lupus erythematosus, Sjögren syndrome, rheumatoid arthritis, mixed connective tissue disease, and/or polymyositis/dermatomyositis; PM/DM, polymyositis/dermatomyositis; RA, rheumatoid arthritis; SD, standard deviation; SLE, systemic lupus erythematosus.
AKI is a significant disease syndrome affecting a large proportion of pediatric ICU patients.
Frailty is a significant geriatric syndrome characterized by age-associated severely reduced strength, 1 mobility, balance, and endurance.
The hSCARB2 transgenic mice were reported to be more susceptible to EV71 infection than the hPSGL1 transgenic mice and resulted in significant neurological syndrome [ 24, 25, 40]; we did not observed these differences in this study.
Hvid et al. [ 22] only followed up individuals with "a significant clinical syndrome" of chondromalacia patellae confirmed on arthrograms, possibly suggesting pre-existing patellofemoral arthropathy, while participants invited for x-ray follow-up by Nimon et al. [ 20] were only that small proportion of 14 out of 49 whose symptoms had got no better over the years.
One study of twins identified three clinically significant depressive syndromes: mild typical depression, atypical depression, and severe typical depression.
There is little information regarding the role of Meprin A in the pathogenesis of significant renal syndromes such as acute renal failure (ARF).
