"significant symptom" is correct and usable in written English.
You can use it to refer to a symptom of a medical condition that is particularly evident or pronounced. For example, "The patient's coughing was a significant symptom of their lung infection."
Cognitive impairment is increasingly recognized as a significant symptom in patients with major depressive disorder (MDD).
Significant symptom construct(s) has/have been identified for each response.
The most significant symptom of the pestilence, Dr. Duncan said, was not buboes but red spots -- often called God's tokens -- on the chest.
Too often, an early significant symptom of a serious illness is ignored or quickly dismissed because the patient is a "hypochondriac".
In some cases one must accept a clinically significant symptom reduction that is short of full symptom remission.
The substitutions made in the Oxford Junior Dictionary – the outdoor and the natural being displaced by the indoor and the virtual – are a small but significant symptom of the simulated screen life many of us live.
Despite greatly improved survival in pediatric patients with end-stage heart failure through the use of ventricular assist devices (VADs), heart failure ultimately remains a life-threatening disease with a significant symptom burden.
All the cases suggested that fasciation is a significant symptom for phytoplasma disease.
These studies showed a decrease in median time to clinically significant symptom relief.
CONCLUSIONS:Hematologic and solid tumor patients have significant symptom burden at time of referral to palliative care services.
As NORML reported, all of the study's participants experienced "clinically significant symptom relief," including reductions in irritability, impulsivity, anxiety, obsessive-compulsive symptoms, and rage outbursts.
