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Pathologists reading this list may agree that the tumors from this list include clinically distinct and significant subclasses of tumors and would be welcome additions to a truly comprehensive nomenclature of neoplastic entities.
Gene expression analyses across glioblastoma multiforme tumors taken in toto has shown that there are significant subclasses of glioblastoma that differ in large ways in gene expression patterns [ 27, 32, 33].
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In this paper, we introduce the elimination algorithm, which performs, in linear time, minimal model finding and minimal model checking for a significant subclass of positive CNF theories which we call positive head-cycle-free (HCF) theories.
Nonetheless, it is known that a significant subclass of \ \textbf{NP}\ -complete problems possess polynomial time approximation algorithms -- i.e. algorithms which are guaranteed to find a solution which is within a certain constant factor of optimality.
The most significant biological function classification was in skeletal and muscular development and function with the most significant subclass being skeletal development (corrected p-value of 2.22×10−9) (Table S7).
Those developing DSSs might reject our blanket category, claiming significant differences between subclasses of these systems (e.g. how a specific tool works or is developed), in the same way that a chemist will recognise molecular differences between the individual drugs that form a single therapeutic class.
In comparison, control cells specific for collagen secreted significant amounts of all subclasses of cytokines, both inflammatory (IFN-γ, IL-17) and noninflammatory (IL-4 and IL-10).
The Knee Injury and Osteoarthritis Outcome score showed significant improvement in the subclasses of pain, other symptoms, and knee-related quality of life 2 years after treatment in focal OA defects.
Our results revealed three subclasses of EAC patients characterized by significant differences in gene expression that correlated with prognosis.
Subclasses of AluS sequences provide a significant source of potential hormone response elements for retinoic acid and thyroid hormone receptors [ 36, 41].
Interestingly, consumption of vegetables per se and specific food components (antioxidant nutrients and various subclasses of flavonoids) failed to show statistically significant relationships with either of the biomarkers.
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