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"significant structural changes" is correct and usable in written English.
You can use this phrase when referring to changes that are conveniently noteworthy in terms of their impact or scope. For example, "The company is undergoing significant structural changes in order to become more competitive."
Exact(60)
It is the Dutch who are most opposed to making significant structural changes.
He was intent on making significant structural changes, including the creation of an 18-by-20-foot 18-by-20-foot 18-by-20-foot 18-by-20-footes.
Last month Birmingham council's chief executive, Mark Rogers, told staff that "significant structural changes" to the local authority's education department were on the cards.
Raman spectroscopy revealed significant structural changes for GC electrodes treated by electrochemical oxidation and abrasive polishing.
And if Republicans agree to a substantial revenue increase in this way, Democrats should agree to significant structural changes to slow the growth of Social Security and Medicare.
China experts say enforcement is necessary given that the United States wants Beijing to make significant structural changes that will take time.
Neo-neo induces significant structural changes in RNA where neomycin binds.
"Product and Engineering are going to make the most significant structural changes to reflect our plan ahead.
They lobby publicly for significant structural changes, hoping to drive up the share price and book quick profits.
Alhough Honda did not completely re-engineer the Odyssey, it made significant structural changes to enhance front-end crash protection.
"I don't think there is going to be a lot of room to maneuver without some significant structural changes".
More suggestions(15)
significant organisational changes
prominent structural changes
significant cultural changes
noticeable structural changes
significant architectural changes
considerable structural changes
important structural changes
huge structural changes
vital structural changes
large structural changes
remarkable structural changes
vast structural changes
significant organizational changes
significant functional changes
major structural changes
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com