Sentence examples for significant structural alteration from inspiring English sources
Hydrogen bonding interactions also contribute significantly to the binding energetics of biotin, and the D128A mutation which breaks a hydrogen bond between the protein and a ureido NH group results in a significant structural alteration that could mimic an intermediate on the dissociation pathway.
β-Aspartyl bond formation leads to significant structural alteration and often dysfunction and is one of the most common nonenzymatic processes by which protein damage occurs.
Altogether, these data indicated an overall preservation of the original protein fold for the WTs and CVs, although a significant structural alteration was observed for FVs and CFVs.
The introduction of a fluorescent dye together with a radiolabel (which is either covalently attached or complexed by a chelator system) can result in a significant structural alteration especially in case of rather small target-specific molecules.
Significant structural alterations in TCR and pMHC, upon complex formation, hint at an as yet unclear role for conformational change in both recognition and activation.
The results revealed that the TGR-based pretreatment led to the significant structural alterations through increases in pore size, pore volume, cellulose crystallinity and surface area.
The Pavillon de Flore has undergone significant structural alterations since its inception, most notably during the reign of Napoléon III, who in 1861 authorized its remodeling under the supervision of architect Hector Lefuel.
The findings have clearly shown significant structural alterations in the left ventricle of AAB hearts.
Currently the only way to fix cellular constituents without introducing significant structural alterations is by cryo-fixation.
Of the 13 substituted proteins we examined, five of them (UbldA31D, UbldR42P, UbldA46P, UbldT55I, and UbldV56E) showed significant structural alterations.
F508 is in the first nucleotide-binding domain (NBD1) of CFTR but no significant structural alterations correlate with its deletion [3].
