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The phrase "significant since" can be used in written English, but it may sound more natural to use "significant because" or "notable since" instead. Example: The company's profits have increased significantly since implementing their new marketing strategy.
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In the US, Medicare was the last serious political advance; there has been nothing significant since.
The inclusion of that last one (and civil aviation) is significant, since it's protected territory of the military.
The surge in discouraged workers is the most significant since the months after the Sept. 11 attacks.
The new television and print campaign for pork is the most significant since the introduction of the "Pork.
Clegg regards the free school meals announcement as one of the most significant since he entered government.
The surge in discouraged workers is the most significant since the months immediately after the recession's start.
Perhaps more significant, since then, we the world's bystanders have known that anything could happen at any time, anywhere.
This is significant, since it reduces borrowing costs for consumers and businesses.
Mr Nutter's endorsement is particularly significant, since he is a reform-minded black.
Nevertheless, unemployment in the state has been significant since the mid-1990s.
That is arguably more significant, since it bears out the recent transformation of Val Thorens.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com