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The phrase "significant shortcomings" is correct and usable in written English.
You can use it to refer to flaws or problems that are particularly important or noteworthy. For example: "The report highlighted significant shortcomings in the company's accounting practices."
Exact(60)
Even so, significant shortcomings remain.
The study had two significant shortcomings.
It worked but had several significant shortcomings.
"All approaches have significant shortcomings," she said, referring to laws in other states.
In reply, the government said the report had significant shortcomings and glossed over recent institutional and legal measures.
But on Monday, the Federal Reserve described some significant shortcomings in the banks' responses to the so-called stress tests.
A14 The Republican chairman of the House Intelligence Committee, Representative Porter Goss of Florida, said that prewar American intelligence about Iraq was hampered by significant shortcomings.
But the Tuesday report, issued by Glenn A. Fine, the inspector general, said the Batres case revealed significant shortcomings in that effort.
But if it fails to require the same of police stops that do not result in arrests or summonses, it has significant shortcomings.
Last month, the Joint Commission, the country's leading health care accrediting agency, raised serious concerns about Grady's status after observing numerous significant shortcomings during a five-day inspection.
He decided to do so after a broader investigation by two retired commanders found significant shortcomings in security throughout the region.
More suggestions(15)
significant drawbacks
huge shortcomings
significant weaknesses
noticeable shortcomings
vast shortcomings
substantial shortcomings
significant defects
significant deficiencies
significant shortages
considerable shortcomings
remarkable shortcomings
salient shortcomings
significant gap
significant deficiency
fundamental shortcomings
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com