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We did not observe significant shift of the mean SDS z-scores (P > 0.30; Supplementary Fig. 6), which might suggest that Neanderthal-derived sequences were not apparently under significant selection pressure in the recent ages in the Japanese population.
As comparisons between LCT, RH and HLA lead to quite similar results, it was possible to conclude to a significant effect of population history, but not to exclude a significant selection pressure on the lactase gene.
This suggests that significant selection pressure exists to maintain them.
This suggests that discriminatory egg puncturing by laying female honeyguides imposes a significant selection pressure on previously laid honeyguide eggs.
Under the M2a and M8 models, some sites of the 2 MHC loci were under significant selection pressure.
This parasite is likely to cause significant selection pressure on Daphnia populations because of its high virulence (up to 95% fecundity reduction, [ 36, 37]).
Similar(45)
Widespread variation of the genes encoding AMA1 proteins from different populations and in more than one species have been reported, providing evidence that this gene, ama1, is under significant selection pressures in natural populations [15], [18], [19].
Here, we analyze the distribution of transcribed pseudogene annotations (TPAs) in the human and mouse genomes, examine their conservation in an expanded panel of mammals (rhesus monkey, mouse, rat, dog and cow), and assess evidence for significant selection pressures.
The comparison to Sowetans in the rheumatoid arthritis study was done primarily with markers related to loci relevant to autoimmune disease, which may have introduced some bias, since they may have been involved in significant selection pressures as highlighted by Schlebusch et al. [ 15].
This difference in environments exerts an important selection pressure.
The most frequently positively selected codons were 384, 397 and 401 (which were under significant positive selection pressure in three out of four subjects), followed by sites 396 and 399, which were positive in two out of four subjects.
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