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This created a significant safety issue.
Poor sun visors are a significant safety issue and ought to be addressed.
But the lack of an exterior passenger-side mirror — another casualty of cost containment — seemed not just a serious nuisance but a significant safety issue.
"Once we had identified this as a significant safety issue, we knew that we couldn't just wait for the convenience of the issuing of a report.
On Nov. 4, a Qantas A380 superjumbo — Airbus's star model — made a successful emergency landing in Singapore in what was the most significant safety issue yet for the giant plane since it began passenger flights in 2007.
The engine explosion was the most significant safety issue an A380 had ever faced since it began passenger flights in 2007 and prompted intense scrutiny of Rolls-Royce engines.
Similar(51)
"Our analysis suggests that there are significant safety issues with a substantial segment of Ford Explorers," Mr. Lampe wrote.
The Health and Safety Executive said that 69 significant safety issues needed to be addressed before the PPP could be allowed to proceed.
The high court injunction prohibiting occupation on campus was sought after a student occupation in November 2011 which raised significant safety issues".
Under the accord, the drug review and drug safety offices will have equal responsibility for "significant safety issues" pertaining to medicines that are under review or have already been approved for marketing.
Pfizer issued a statement on Friday saying that three trials involving a total of 6,000 patients that have been under way for several years had not shown any significant safety issues.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com