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At the same time, the value of estimated safety benefits can be considered as conservative as it is related only to those treatments for which significant safety effects were found by the study.
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This created a significant safety issue.
However, even small safety effects can be significant when, as we assume will happen in the future, the systems are introduced as combinations or bundles, especially when individual systems in a bundle target different type of accidents.
Two recent examples of clinical adverse effects which caused significant safety problems in large numbers of individuals, were osteonecrosis of the jaw with bisphosphonates and increased risk of myocardial infarction following rofecoxib use.
There were no unexpected adverse effects of riluzole, and no significant safety concerns.
The final values of safety effects produced by the study are statistically significant and comparable with international and/or previous local experience.
For each of the treatment types associated with a significant accident reduction, in the current study, detailed values of safety effects were collected from other sources.
These odd vehicles pose significant safety risks.
These safety effects require further study.
In addition, there are significant safety concerns".
There were no significant safety issues.
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