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Among the most significant replicating models was rs12597188 (intron of CDH1)–rs11564445 (intron of CTNNB1).
The intronic SNPs of EGF and EGFR, rs3796947 and rs6954351, respectively, were among the five most significant replicating models in the discovery dataset.
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miR-18a, miR-181a, and miR-222 showed the highest percentage difference between cases and controls in our study; qRT-PCR of these miRNAs in a small independent replication set of cases and controls, though not statistically significant, replicated the direction of change for all three.
Power was defined as the proportions of significant replicates at the nominal level 0.05.
This difference between the two ecotypes in exploratory behavior was significant (GLZ: χ(1) = 5.37; P = 0.021), and there was no significant replicate effect (χ(5) = 4.17; P = 0.124).
For highly significant replicates, estimates from pooled data are less significant than those from individual data.
The 122 genes represented by significant replicate spot features were classified using gene ontology (GO).
Ninety of the 122 genes represented by significant replicate spot features were expressed at lower levels in BTB-infected animals (Fig. 2).
This AluYb8 insertion showed significant replicated association with blood pressure and a potential effect on the expressional profile of alternative WNK1 transcripts in leucocytes.
Figure 2 shows the P-value and hazard ratio (HR) distribution (Cox proportional hazards model) of all drugs after selecting the most significant replicate.
Region 5, which illustrates univariate associations between the SNPs and ABI, reveals that only two SNPs in NOS3 (which are in LD) have significant, replicated and cross-validated associations.
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